What is Progesterone Gel and How Does it Work? Progesterone gel is commonly prescribed in hormone replacement therapy (HRT) and fertility treatments. Progesterone is a naturally occurring hormone crucial for regulating the menstrual cycle and maintaining pregnancy. For women experiencing progesterone deficiency due to menopause or other hormonal imbalances, progesterone gel offers an effective solution. This topical treatment delivers the hormone directly through the skin, where it is absorbed into the bloodstream. The primary use of progesterone gel is to supplement or replace the natural production of progesterone in women. It is often prescribed in conjunction with estrogen in HRT to balance hormone levels and alleviate symptoms of menopause, such as hot flashes, mood swings, and irregular periods. It also plays an essential role in supporting the uterine lining, which is vital for women undergoing fertility treatments like in-vitro fertilization (IVF). By thickening the...